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How to Use the Dihydrorhodamine (DHR) Collection Kit

With a simple blood draw from both a suspected chronic granulomatous disease (CGD) patient and a healthy control individual, the DHR test can identify CGD or evaluate the risk of infection in an X-linked carrier.

  • HCPs
  • PATIENTS
  • LAB STAFF
  • Transcript

    Dihydrorhodamine (DHR) Collection Kit directions.

    The dihydrorhodamine or DHR test is a blood test used to test for chronic granulomatous disease (CGD). It can also detect the type of CGD or carrier status.

    The DHR Collection Kit is used to collect and ship blood samples to be tested for CGD using the DHR test.

    In this video, we will go over the correct way for the HCP, patient, and lab staff who draw the blood to use the kit. This will help ensure the samples are processed and tested properly.

    DHR Collection Kit directions for healthcare professionals (HCPs).

    Before the kit can be used, the HCP must complete the ARUP requisition form and include the completed form with the kit to ensure that the test is processed correctly. Incomplete forms may prevent test processing.

    This DHR test is valid for CGD testing only.

    HCPs will determine if their office is equipped to perform the blood draw. If not, Horizon Therapeutics has partnered with Quest Diagnostics Patient Service Centers where the patient and donor will need to go to for the blood draw. Check the INSTRUCTIONS FOR USING YOUR DHR COLLECTION KIT card to make sure the correct forms are completed based on where the blood draw will be performed. HCPs should also review the patient instructions included in the kit with the patient or caregiver before the blood draw appointment.

    Inform patients or caregivers that they need to bring a nonrelated, healthy donor with them for the blood draw.

    If the blood draws will not be performed in the HCP’s office, details on how to make an appointment and locate the nearest Quest Diagnostics Patient Service Center are included in the patient instructions.

    If the blood draw is performed in the HCP’s office, office staff MUST immediately call FedEx to arrange for same-day pickup to ensure neutrophils are processed within 24 to 36 hours.

    Whether the patient is going to a Patient Service Center or Quest Diagnostics for the blood draw, in addition to the ARUP Laboratory Requisition Form, the HCP also needs to fill out the Quest Diagnostics Lab Order Form provided in the kit.

    Both forms must be completed in full and match.

    Then give the DHR Collection Kit to the patient. The patient must bring the entire kit—including the 2 completed forms from their HCP’s office—with them for the blood draw.

    Once the samples from the DHR Collection Kit have been received and processed, results will be sent to the ordering HCP via fax from ARUP Laboratories within 2 to 3 days.

    The ordering HCP can request an enhanced report, including a histogram, by calling ARUP Client Services at 1-800-522-2787 and providing the Horizon Client ID.

    If you have any questions, review the checklist below this video.

    CGD Pathways is proud to offer the DHR Collection Kit free of charge.

  • Transcript

    Dihydrorhodamine (DHR) Collection Kit directions.

    The dihydrorhodamine or DHR test is a blood test used to test for chronic granulomatous disease (CGD). It can also detect the type of CGD or carrier status.

    The DHR Collection Kit is used to collect and ship blood samples to be tested for CGD using the DHR test.

    In this video, we will go over the correct way for the HCP, patient, and lab staff who draw the blood to use the kit. This will help ensure the samples are processed and tested properly.

    DHR Collection Kit directions for healthcare professionals (HCPs).

    Before the kit can be used, the HCP must complete the ARUP requisition form and include the completed form with the kit to ensure that the test is processed correctly. Incomplete forms may prevent test processing.

    This DHR test is valid for CGD testing only.

    HCPs will determine if their office is equipped to perform the blood draw. If not, Horizon Therapeutics has partnered with Quest Diagnostics Patient Service Centers where the patient and donor will need to go to for the blood draw. Check the INSTRUCTIONS FOR USING YOUR DHR COLLECTION KIT card to make sure the correct forms are completed based on where the blood draw will be performed. HCPs should also review the patient instructions included in the kit with the patient or caregiver before the blood draw appointment.

    Inform patients or caregivers that they need to bring a nonrelated, healthy donor with them for the blood draw.

    If the blood draws will not be performed in the HCP’s office, details on how to make an appointment and locate the nearest Quest Diagnostics Patient Service Center are included in the patient instructions.

    If the blood draw is performed in the HCP’s office, office staff MUST immediately call FedEx to arrange for same-day pickup to ensure neutrophils are processed within 24 to 36 hours.

    Whether the patient is going to a Patient Service Center or Quest Diagnostics for the blood draw, in addition to the ARUP Laboratory Requisition Form, the HCP also needs to fill out the Quest Diagnostics Lab Order Form provided in the kit.

    Both forms must be completed in full and match.

    Then give the DHR Collection Kit to the patient. The patient must bring the entire kit—including the 2 completed forms from their HCP’s office—with them for the blood draw.

    Once the samples from the DHR Collection Kit have been received and processed, results will be sent to the ordering HCP via fax from ARUP Laboratories within 2 to 3 days.

    The ordering HCP can request an enhanced report, including a histogram, by calling ARUP Client Services at 1-800-522-2787 and providing the Horizon Client ID.

    If you have any questions, review the checklist below this video.

    CGD Pathways is proud to offer the DHR Collection Kit free of charge.

  • Transcript

    Dihydrorhodamine (DHR) Collection Kit directions.

    The dihydrorhodamine or DHR test is a blood test used to test for chronic granulomatous disease (CGD). It can also detect the type of CGD or carrier status.

    The DHR Collection Kit is used to collect and ship blood samples to be tested for CGD using the DHR test.

    In this video, we will go over the correct way for the HCP, patient, and lab staff who draw the blood to use the kit. This will help ensure the samples are processed and tested properly.

    DHR Collection Kit directions for healthcare professionals (HCPs).

    Before the kit can be used, the HCP must complete the ARUP requisition form and include the completed form with the kit to ensure that the test is processed correctly. Incomplete forms may prevent test processing.

    This DHR test is valid for CGD testing only.

    HCPs will determine if their office is equipped to perform the blood draw. If not, Horizon Therapeutics has partnered with Quest Diagnostics Patient Service Centers where the patient and donor will need to go to for the blood draw. Check the INSTRUCTIONS FOR USING YOUR DHR COLLECTION KIT card to make sure the correct forms are completed based on where the blood draw will be performed. HCPs should also review the patient instructions included in the kit with the patient or caregiver before the blood draw appointment.

    Inform patients or caregivers that they need to bring a nonrelated, healthy donor with them for the blood draw.

    If the blood draws will not be performed in the HCP’s office, details on how to make an appointment and locate the nearest Quest Diagnostics Patient Service Center are included in the patient instructions.

    If the blood draw is performed in the HCP’s office, office staff MUST immediately call FedEx to arrange for same-day pickup to ensure neutrophils are processed within 24 to 36 hours.

    Whether the patient is going to a Patient Service Center or Quest Diagnostics for the blood draw, in addition to the ARUP Laboratory Requisition Form, the HCP also needs to fill out the Quest Diagnostics Lab Order Form provided in the kit.

    Both forms must be completed in full and match.

    Then give the DHR Collection Kit to the patient. The patient must bring the entire kit—including the 2 completed forms from their HCP’s office—with them for the blood draw.

    Once the samples from the DHR Collection Kit have been received and processed, results will be sent to the ordering HCP via fax from ARUP Laboratories within 2 to 3 days.

    The ordering HCP can request an enhanced report, including a histogram, by calling ARUP Client Services at 1-800-522-2787 and providing the Horizon Client ID.

    If you have any questions, review the checklist below this video.

    CGD Pathways is proud to offer the DHR Collection Kit free of charge.

Note: The dihydrorhodamine (DHR) test can help distinguish X-linked and autosomal recessive forms of CGD and evaluate the risk of infection in X-linked carriers.


HEALTHCARE PROFESSIONALS: Tips for healthcare professionals on the proper use of the DHR Collection Kit

DHR Collection Kits are sent directly to healthcare professionals, who either perform the blood draw in their offices or send the collection kit to a laboratory. Because the testing process has some very specific steps, it’s important that healthcare professionals, patients, and laboratory staff know how to use the collection kit properly. A control sample is required.

ARUP-requisition-icon

Complete the ARUP requisition form before patients get their blood drawn to ensure that the kit is processed correctly. If the blood draw is occurring at a Quest Diagnostics Patient Service Center, fill out the Quest coupon in order for the test to be performed at no cost.

patient-instructions-icon

Review the patient instructions included in the kit with patients.

dhr-collection-kit-and-associated-paperwork-icon

Give the entire DHR Collection Kit and associated paperwork to patients to take to their appointment.

Note: Testing for CGD while the patient has an active infection is not recommended.

Communication of results

Results will be provided via email or fax and will include an enhanced report with laboratory results and histograms.

For questions about results, contact ARUP Client Services at 1 (800) 522-2787.

  • ARUP is available 24 hours a day, 365 days a year
  • Visit www.aruplab.com
  • Test code: 0096657 (neutrophil oxidative burst assay)
  • CPT code: 82657

Order a DHR test for CGD at no cost

PATIENTS: Tips for the proper use of the DHR Collection Kit

DHR Collection Kits are sent directly to healthcare professionals, who either perform the blood draw in their offices or send the collection kit to a laboratory. Because the testing process has some very specific steps, it’s important that healthcare professionals, patients, and lab staff know how to use the collection kit properly.

patient-DHR-Collection-Kit-step-1

Find a healthy, nonrelated control donor to take the test at the same time as you or your child.

  • Two samples of blood must be collected: 1 from the patient and 1 from the donor
  • If a patient needs to go to a Quest Diagnostics Patient Service Center for their blood draw, they should schedule 1 appointment for both blood draws
patient-DHR-Collection-Kit-step-2

Schedule blood draw for Monday through Thursday before 2 PM so the blood sample can be shipped the same day.

  • Blood-draw appointments should not be scheduled on Fridays, weekends, the day before a holiday, or late in the afternoon
patient-DHR-Collection-Kit-step-3

Patients should bring the entire DHR Collection Kit to their blood draw, including the:

  • Completed requisition form (“ARUP Only” envelope)
  • “Patient Instructions” envelope
  • Quest envelope for the lab staff if a Quest Diagnostics Patient Service Center is being used

Patients with questions about the test or test results should contact their healthcare professionals.

LAB STAFF: Tips for the proper use of the DHR Collection Kit

DHR Collection Kits are sent directly to healthcare professionals, who either perform the blood draw in their offices or send the collection kit to a laboratory. Because the testing process has some very specific steps, it’s important that healthcare professionals, patients, and lab staff know how to use the collection kit properly.

lab-staff-DHR-Collection-Kit-step-1

Do NOT do any of the following to blood samples: refrigerate, freeze, add coolant, spin in a centrifuge, or shake.

lab-staff-DHR-Collection-Kit-step-2

Lab staff MUST ship the DHR Collection Kit the same day that blood is drawn. Overnight shipping should be used to ensure that blood samples arrive for analysis the day after the blood is drawn. A prepaid FedEx® label is included in the kit and lab staff must call FedEx to ensure same-day pickup of the completed kit.

Lab staff with questions about specimen processing should call ARUP at 1 (800) 522-2787. Please provide client ID 282419 and mention Horizon when calling.